COMPARATIVE STUDY OF THE LOADING AMOUNT OF DRUG WITHIN MESOPOROUS SILICA WITH VARIOUS PORE SIZE

Objective: The loading of drugs into mesoporous silica (MS) is an effective strategy to improve the solubility poorly water-soluble drugs. Previous reports have stated that surface area and pore volume MS can affect drug its crystallization in MS. Therefore, this study aims elucidate effect size on maximum dissolution profile. Methods: ritonavir (RTV) itraconazole (ITZ) were encapsulated-MS using solvent evaporation method. RTV ITZ loaded-MS characterized differential scanning calorimetry (DSC) PXRD measurement. Results: amorphization loaded-MPS confirmed as a halo pattern powder X-ray diffraction pattern. melting peak glass transition not discovered with 80 Å (weight ratio 3:7), while 45 Å, observed. This indicated amount larger sizes higher than lower sizes. Conclusion: demonstrated has significant